In the presentation, entitled Precise excision of targeted RNA by third generation antisense (3GA) oligonucleotides, Idera scientists presented data that demonstrated that gene-silencing by 3GAs led to excision sites in the targeted mRNA in the region similar to that observed with siRNA. These excision products are different from those observed with earlier generations of antisense. This presentation also provided a demonstration of 3GAs specificity by showing that the incorporation of a mismatch at the region of excision led to the loss of gene-silencing activity. Based on these studies, the company is also conducting studies to further the potential applications of 3GAs in targeting diseases caused by point mutations. Data from these studies is expected to be presented in the second half of 2016. This presentation is currently available on Ideras website at http://www.iderapharma.com/our-science/key-presentations-and-publications . Our in-depth understanding from our pioneering work in antisense technology along with our insights into the interaction of nucleic acids with Toll-like receptors has allowed us to design this very unique technology platform to fully realize the potential of antisense technology, stated Sudhir Agrawal, D. Phil., President of Research at Idera Pharmaceuticals. We are continuing to conduct preclinical studies with multiple 3GA candidates in house and with our collaborators, with a goal of advancing this technology to clinical development. Previously the company has announced the identification of NLRP3 (NOD-like receptor family, pyrin domain containing protein 3) and DUX4 (Double Homeobox 4) as initial gene targets to advance into IND-enabling activities, which will occur throughout 2016. Potential disease indications related to these targets include, but are not limited to, interstitial cystitis, lupus nephritis, uveitis and facioscapulohumeral muscular dystrophy (FSHD). The Company is currently conducting clinical, regulatory and commercial analysis activities and conducting IND-enabling studies with the plan to enter the clinic in 2017 for the first clinical development program. In addition to these activities, over the first half of 2016, Idera generated 3GA compounds for a series of additional gene targets. These will enable the Company to continue to expand its future pipeline opportunities for both internal development as well as partnerships in areas outside of Ideras focus. Additionally, Idera is party to a collaboration and license agreement with GSK to research, develop and commercialize compounds from its 3GA technology for the treatment of undisclosed, selected renal targets. no dataAbout Ideras Third Generation Antisense Platform (3GA) Ideras proprietary third-generation antisense (3GA) platform technology is focused on silencing the mRNA associated with disease causing genes. Idera has designed 3GA oligonucleotides to overcome specific challenges associated with earlier generation antisense technologies and RNAi technologies. About Idera Pharmaceuticals, Inc. Idera Pharmaceuticals is a clinical-stage biopharmaceutical company developing novel nucleic acid-based therapies for the treatment of certain cancers and rare diseases. Ideras proprietary technology involves using a TLR-targeting technology, to design synthetic oligonucleotide-based drug candidates to act by modulating the activity of specific TLRs. In addition to its TLR programs, Idera has created a third generation antisense technology platform using its proprietary technology to inhibit the production of disease-associated proteins by targeting RNA.
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Classification.nd symptoms and signs of uveitis. downer BC, Mae R, Becket MD, Heinz C, Veltrup I, Heiligenhaus A, Barisani-Asenbauer T, Mackensen F. mosey; 2008. Depending on your symptoms, any of these treatments might be used for intermediate uveitis. Posterior uveitis – the least common type. Editorial team. However, the disease isn’t just limited to the urea, it can also affect the lens, retina, optic nerve and vitreous. Uveitis is inflammation of the urea, which is made up of the iris, biliary body and choroid. Some people have minor problems with their eyesight . This guide provides information about uveitis. Am J Ophthalmol. 1996 Aug. 1222:171-82. Herbal Medicine: Expanded Commission E Monographs. How do Eye Doctors Treat Uveitis?
Robert E O’Connor, MD, MPH Professor and Chair, Department of Emergency Medicine, University of Virginia Health System Disclosure: Nothing to disclose. Still other types never completely subside and linger for years, requiring chronic treatment to prevent flare-ups. Usually other agents are started if it appears that patients need moderate or high doses of oral steroids for more than 3 months. It affects children, working adults, and senior citizens. Also, diseases that damage the body’s immune system, such as AIDS, can lower the body’s ability to protect itself from infections that can cause uveitis. Each type is classified by where the inflammation occurs in the eye. http://dclakers.com/aidengarciaville/2016/08/05/but-if-you-have-diabetes-high-blood-pressure-or-other-conditions-you-should-seek-an-eye-exam-yearly/Tell your provider about any herbs or supplements you use or plan to use. The medications used to treat uveitis have side effects of their own, some of them serious.